Production of Pure Aqueous 13 C-Hyperpolarized Acetate by Heterogeneous Parahydrogen-Induced Polarization
نویسندگان
چکیده
منابع مشابه
Demonstration of Heterogeneous Parahydrogen Induced Polarization Using Hyperpolarized Agent Migration from Dissolved Rh(I) Complex to Gas Phase
Parahydrogen-induced polarization (PHIP) was used to demonstrate the concept that highly polarized, catalyst-free fluids can be obtained in a catalysis-free regime using a chemical reaction with molecular addition of parahydrogen to a water-soluble Rh(I) complex carrying a payload of compound with unsaturated (C═C) bonds. Hydrogenation of norbornadiene leads to formation of norbornene, which is...
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Introduction: Hyperpolarized contrast media based on nuclei such as C yield significant enhancements of signal-to-noise ratio in MRI (1). These agents are beginning to show promise for a variety of applications, including real-time metabolic imaging (2) and cancer imaging (3). One challenge to the widespread application of these agents is the relatively short spin-lattice (T1) relaxation time o...
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Where tanh is the hyperbolic tangens function, h the Planck constant, BBo is the main magnetic field strength, kBB the Boltzmann constant and T is the temperature. At a magnetic field of 1.5 T the polarization of the protons (H) at body temperature is only ∼5 x 10 and for C ∼1.0 x 10. The polarization is proportional to the magnetic field strength. Consequently, a 3 T scanner will result in a d...
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Long-lived spin states of hyperpolarized propane-d6 gas were demonstrated following pairwise addition of parahydrogen gas to propene-d6 using heterogeneous parahydrogen-induced polarization (HET-PHIP). Hyperpolarized molecules were synthesized using Rh/TiO2 solid catalyst with 1.6 nm Rh nanoparticles. Hyperpolarized (PH ∼ 1%) propane-d6 was detected at high magnetic field (9.4 T) spectroscopica...
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Magnetic resonance angiography (MRA) is a non-invasive technology that can be used for diagnosis and monitoring of cardiovascular disease; the number one cause of mortality worldwide. Hyperpolarized imaging agents provide signal enhancement of more than 10, 000 times, which implies large reduction in acquisition time and improved spatial resolution. We review the role of hyperpolarized 13C agen...
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ژورنال
عنوان ژورنال: Chemistry - A European Journal
سال: 2016
ISSN: 0947-6539
DOI: 10.1002/chem.201603974